| ECS | Electronic Clearing Service |
| ESI | Employees' State Insurance |
| EDGE | Enhanced Data Rates for GSM Evolution |
| EDP | Electronic Data Processing |
| ETA | Estimated Time of Arrival |
| ECC | Excise Control Code |
| ECC | Error Correcting Code |
| ECC | ERP (Enterprise Resource Planning) Central Component |
| EMI | Equated Monthly installment |
| EOD | End of the Day |
| EBV | Epstein - Barr virus |
| ECT | Electroconvulsive Therapy |
| ENT | Ear Nose Throat |
| EPFO | Employee Provident Fund Organization |
| ERP | Enterprise Resource Planning |
| EJB | Enterprise Java Beans |
| EVM | Electronic Voting Machine |
| EEG | Electroencephalogram |
| EOBD | End of Business Day |
| EOD | End of Discussion |
| EOM | End of Message |
| ECG | Electrocardiography |
| EASST Time Zone | Easter Island Summer Time (Daylight Saving Time) |
| EAST Time Zone | Easter Island Standard Time (Standard Time) |
| EAT Time Zone | Eastern Africa Time (Standard Time) |
| EDT Time Zone | Eastern Daylight Time / Eastern Daylight Savings Time (Daylight Saving Time) |
| EEST Time Zone | Eastern European Summer Time (Daylight Saving Time) |
| EET Time Zone | Eastern European Time (Standard Time) |
| EGST Time Zone | Eastern Greenland Summer Time (Daylight Saving Time) |
| EGT Time Zone | East Greenland Time (Standard Time) |
| EST Time Zone | Eastern Standard Time / Eastern Time (Standard Time) |